Israel police have deployed thousands of police officers in Jerusalem for the U.S. embassy relocation ceremony.
According to health officials, at least 52 Palestinians have been killed along the Gaza Strip during demonstrations against the beginning of the relocation of the U.S. Embassy from Tel Aviv to Jerusalem.
It was the highest Palestinian death toll in a single day since a series of protests dubbed the "Great March of Return" began at the border with Israel on March 30, and since the 2014 Gaza war.
The health officials said over 2,000 Palestinians were wounded, about 450 of them by live bullets.
Palestinians have long viewed East Jerusalem as the true capital of a future Palestinian State.